Response of cardiac sympathetic nerve activity to intravenous irbesartan in heart failure

R Ramchandra; AMD Watson; SG Hood; CN May

Journal article

Response of cardiac sympathetic nerve activity to intravenous irbesartan in heart failure

R Ramchandra, AMD Watson, SG Hood, CN May

American Journal of Physiology Regulatory Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2010

DOI: 10.1152/ajpregu.00767.2009

Abstract

To determine the effect of irbesartan treatment on resting levels and arterial baroreflex control of cardiac sympathetic nerve activity (CSNA) in heart failure (HF), we studied conscious normal sheep and sheep with HF induced by rapid ventricular pacing for 8-10 wk (n = 7 per group). In HF, there is a large increase in CSNA that is detrimental to outcome. The causes of this increase in CSNA and the effect of angiotensin receptor blockers on CSNA in HF are unclear. CSNA, arterial blood pressure, heart rate (HR), and arterial baroreflex curves were recorded during a resting period and after 90 min of irbesartan infusion (12 mg·kg-1·h-1 iv). This dose of irbesartan abolished the pressor respons..

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University of Melbourne Researchers

Clive May Author

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Awarded by National Heart, Lung, and Blood Institute

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia Grants 232313 and 509204 and National Heart, Lung, and Blood Institute Grant 5-R01 HL-074932. R. Ramchandra was the recipient of National Heart Foundation Postdoctoral Fellowship 07M 3293, and C. N. May was supported by National Health and Medical Research Council Research Fellowships 350328 and 566819.