Journal article
Early expression of the androgen receptor in the sertoli cells of a Marsupial Coincides with downregulation of anti-müllerian hormone at the time of urogenital virilization
C Racine, AJ Pask, GE Wijayanti, N Di Clemente, JY Picard, G Shaw, MB Renfree, N Josso
Sex. Dev. | Published : 2009
DOI: 10.1159/000273263
Abstract
Anti-Müllerian hormone (AMH), responsible for the regression of Müllerian ducts, is strongly expressed by eutherian fetal and postnatal Sertoli cellsBoth AMH and testosterone levels are high during the period of fetal reproductive tract virilization which occurs largely in utero in eutherian mammalsTaking advantage of the fact that differentiation of the urogenital tract occurs after birth in marsupials, we studied the ontogeny and regulation of AMH in the tammar wallaby testis and related it to the expression of the androgen receptor in Sertoli cellsTesticular AMH expression was high between days 10-30 post partum, then fell to basal levels by day 60 and remained low until day 90, the oldes..
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Awarded by Partenariat Hubert Curien franco-australien
Awarded by Department of Education Science and Training of Australia
Funding Acknowledgements
This work was supported in part by a grant from the Partenariat Hubert Curien franco-australien (PHC 2007 31QJ) and a FAST grant (13909) from the Department of Education Science and Training of Australia. We are grateful to Kerry Martin and Scott Brownlees for expert animal care and to many members of the Wallaby Group in Melbourne for their kindness in providing specimens. Dominique Treton provided excellent technical support and Dr. Daniele Carre-Eusebe helpful advice for in situ hybridization. M. B. R. was supported by an Australian Research Council Federation Fellowship, and A. J. P. by an Australian National Health and Medical Research Council R. D. Wright Fellowship. Animals were held under permits from the Victorian Department of Sustainability and Environment. We are grateful to Dr. J. D. Wilson for his guidance during the course of this work and to Dr. Michael McPhaul for the gift of androgen receptor antibody.