Journal article

Proteomic Analysis of the Intestinal Adaptation Response Reveals Altered Expression of Fatty Acid Binding Proteins Following Massive Small Bowel Resection

Andrew N Stephens, Prue M Pereira-Fantini, Guineva Wilson, Russell G Taylor, Adam Rainczuk, Katie L Meehan, Magdy Sourial, Peter J Fuller, Peter G Stanton, David M Robertson, Julie E Bines

JOURNAL OF PROTEOME RESEARCH | AMER CHEMICAL SOC | Published : 2010

Abstract

Intestinal adaptation in response to the loss of the small intestine is essential to restore enteral autonomy in patients who have undergone massive small bowel resection (MSBR). In a proportion of patients, intestinal function is not restored, resulting in chronic intestinal failure (IF). Early referral of such patients for transplant provides the best prognosis; however, the molecular mechanisms underlying intestinal adaptation remain elusive and there is currently no convenient marker to predict whether patients will develop IF. We have investigated the adaptation response in a well-characterized porcine model of intestinal adaptation. 2D DIGE analysis of ileal epithelium from piglets rec..

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