Proteomic Analysis of the Intestinal Adaptation Response Reveals Altered Expression of Fatty Acid Binding Proteins Following Massive Small Bowel Resection
Andrew N Stephens, Prue M Pereira-Fantini, Guineva Wilson, Russell G Taylor, Adam Rainczuk, Katie L Meehan, Magdy Sourial, Peter J Fuller, Peter G Stanton, David M Robertson, Julie E Bines
JOURNAL OF PROTEOME RESEARCH | AMER CHEMICAL SOC | Published : 2010
Intestinal adaptation in response to the loss of the small intestine is essential to restore enteral autonomy in patients who have undergone massive small bowel resection (MSBR). In a proportion of patients, intestinal function is not restored, resulting in chronic intestinal failure (IF). Early referral of such patients for transplant provides the best prognosis; however, the molecular mechanisms underlying intestinal adaptation remain elusive and there is currently no convenient marker to predict whether patients will develop IF. We have investigated the adaptation response in a well-characterized porcine model of intestinal adaptation. 2D DIGE analysis of ileal epithelium from piglets rec..View full abstract
Dr. Andrew Stephens is supported an Ovarian Cancer Research Foundation fellowship. Dr Prue Pereira-Fantini is supported on a grant provided by the Murdoch Children's Research Institute. Professor Peter Fuller and Associate Professor David Robertson a re Supported by career fellowships from the National Health and Medical Research Council of Australia.