Journal article
Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy
HA Karunajeewa, S Salman, I Mueller, F Baiwog, S Gomorrai, I Law, M Page-Sharp, S Rogerson, P Siba, KF Ilett, TME Davis
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2010
DOI: 10.1128/AAC.01269-09
Abstract
In order to determine the pharmacokinetic disposition of chloroquine (CQ) and its active metabolite, desethylchloroquine (DECQ), when administered as intermittent presumptive treatment in pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were administered three daily doses of 450 mg CQ (8.5 mg/kg of body weight/day) in addition to a single dose of sulfadoxine-pyrimethamine. For all women, blood was taken at baseline; at 1, 2, 4, 6, 12, 18, 24, 30, 48, and 72 h posttreatment; and at 7, 10, 14, 28, and 42 days posttreatment. Plasma was subsequently assayed for CQ and DECQ by high-performance liquid chroma..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
The study was funded by the National Health and Medical Research Council of Australia (grant 458555). T. M. E. D. is supported by a National Health and Medical Research Council of Australia Practitioner Fellowship.