Journal article
11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage
JV Ly, GA Donnan, VL Villemagne, JA Zavala, H Ma, G O'Keefe, SJ Gong, RM Gunawan, T Saunder, U Ackerman, H Tochon-Danguy, L Churilov, TG Phan, CC Rowe
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2010
Abstract
Background: The in vivo diagnosis of cerebral amyloid angiopathy (CAA) is inferred from clinical and structural imaging features. C-Pittsburgh compound B (PIB) is a PET ligand that binds to β-amyloid in extracellular plaques and vessel walls. We hypothesized that patients with a clinical diagnosis of CAA-related hemorrhage (CAAH) have increased C-PIB uptake and that the pattern differs from Alzheimer disease (AD). Methodology: Patients with CAAH based on established clinical criteria were studied using C-PIB PET and were compared with age-matched controls and patients with AD. Distribution volume ratio (DVR) parametric maps were created using the cerebellar cortex as a reference region. Resu..
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Funding Acknowledgements
Study funding: Supported by a Pfizer Cardio Vascular Lipid (CVL) research grant and the National Health and Medical Research Council. The sponsor had no part in the design of the study, data collection, analysis, interpretation of data, writing of this report or the decision to submit the paper for publication.