Journal article
Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes fails to predict breast cancer recurrence: A final analysis of a prospective multi-institutional cohort study
CS Fisher, DJ Cole, M Mitas, E Garrett-Meyer, JS Metcalf, WE Gillanders, K Mikhitarian, MM Urist, GB Mann, G Doherty, VM Herrmann, AD Hill, O Eremin, M El-Sheemy, RK Orr, AA Valle, MA Henderson, RL Dewitty, SL Sugg, E Frykberg Show all
Annals of Surgical Oncology | Published : 2010
Abstract
Background: To address the clinical relevance of molecular detection of occult breast cancer in sentinel lymph nodes and nonsentinel axillary lymph nodes (ALN), we initiated the Minimally Invasive Molecular Staging of Breast Cancer (MIMS) trial, a multi-institutional prospective cohort study. This trial represents the first prospective cohort study in which a multimarker, real-time reverse transcription polymerase chain reaction (RT-PCR) analysis was applied to the detection of breast cancer micrometastases in ALN. Materials and Methods: Sentinel and/or nonsentinel ALN from 501 breast cancer subjects with T1-T3 primary tumors were analyzed by standard histopathology and multimarker, real-tim..
View full abstractGrants
Awarded by U.S. Department of Defense
Funding Acknowledgements
This study was support by the grant from Department of Defense N00014-99-1-0784.