Journal article
Noncovalent liposome linkage and miniaturization of capsosomes for drug delivery
L Hosta-Rigau, R Chandrawati, E Saveriades, PD Odermatt, A Postma, F Ercole, K Breheney, KL Wark, B Städler, F Caruso
Biomacromolecules | AMER CHEMICAL SOC | Published : 2010
DOI: 10.1021/bm101020e
Abstract
We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMAc) to noncovalently anchor liposomes to polymer layers. We subsequently assembled ∼1μm diameter PMAc-based capsosomes, polymer hydrogel capsules that contain up to ∼2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-de..
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Funding Acknowledgements
This work was supported by the Australian Research Council under the Federation Fellowship and Discovery Project schemes. We gratefully acknowledge PharmaMar S.A. for providing the compound Thiocoraline. Prof. Fernando Albericio (Barcelona Science Park) is acknowledged for helpful discussions.