Journal article
Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The australian twins eye study
C Sun, AL Ponsonby, SA Brown, LS Kearns, JR MacKinnon, JM Barbour, JB Ruddle, AW Hewitt, MJ Wright, NG Martin, T Dwyer, DA MacKey
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2010
Abstract
Purpose To examine the relationship of birth weight with ocular measures in a Caucasian twin population. Design Cross-sectional study of 1498 twins (308 monozygotic and 441 dizygotic pairs) aged between 5 to 80 years participating in the Australian Twins Eye Study. Methods All participants underwent ophthalmic examination including bilateral cycloplegic autorefraction, keratometry, interpupillary distance (IPD), central corneal thickness, intraocular pressure (IOP), and retinal photography. Birth weight and gestation were obtained from a self-administered questionnaire. A subset of the twins also participated in the Tasmanian Infant Health Study (288) and the Childhood Blood Pressure Study (..
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Awarded by National Eye Institute
Funding Acknowledgements
THE AUSTRALIAN TWIN REGISTRY IS SUPPORTED BY A NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL (NHMRC) Enabling Grant (2004-2009), Australia. We also thank the following organizations for their financial support: Clifford Craig Medical Research Trust, Launceston, Australia; Cphthalmic Research Institute of Australia (ORIA), Sydney, Australia; Foundation for Children, Sydney, Australia; Peggy and Leslie Cranbourne Foundation, Melbourne, Australia; NHMRC (Project Grant 2005 -2007) Australia; Jack Brockhoff Foundation, Melbourne, Australia; National Eye Institute (NEI) Project Grant (2007-2010), Bethesda, Maryland, USA; and the American Health Assistance Foundation (AHAF), Maryland, USA. Centre for Eye Research Australia receives operational infrastructure support from the Victorian government. David Mackey is the recipient of the Pfizer Australia Senior Research Fellowship. Involved in conception and design (C.S., A.L.P., A.W.H., D.A.M.); data collection (C.S., S.A.B., L.S.K., J.R.M., J.M.B., J.B.R., A.W.H., D.A.M.); analysis and interpretation of the data and drafting of the manuscript (C.S., A.L.P., A.W.H., T.D., D.A.M.); and critical revision of the manuscript for important intellectual content (C.S., A.L.P., J.R.M., A.W.H., N.G.M., M.J.W., T.D., D.A.M.). Written informed consent was obtained from all participants or their legal guardians, with the participants' assent prior to examination. This study was approved by the Human Research ethics committees of the Royal Victorian Eye and Ear Hospital, the Royal Hobart Hospital and the University of Tasmania, and the Queensland Institute of Medical Research, as well as the Australian Twin Registry, and adhered to the tenets of the Declaration of Helsinki. The authors thank the participants in the ATES for their important contributions. We would also like to thank Fleur O'Hare, Sandra Staffieri, Johan Poulsen, Justin Sherwin, Robert Macmillan, Byoung Sung Chu, Katherine Smallcombe, Olivia Bigault, Colleen Wilkinson, Robin Wilkinson, Rachael Adams, Robyn Troutbeck, Jonathan Yeoh, Ya Ling Ma, Trent Roydhouse, Lindsey Scotter, Katarina Crease, Vishal Jhanji, Sonya Bennett, Christine Chen, Ann Eldridge, Marlene Grace, Yingfeng Zheng, Jian Zhang, Mingguang He, and Amy Cohn for helping examine twins. In addition, we appreciate the assistance in recruiting twins from Thanuja Gunasekera, Jenny Boadle, Kim Dorrell, Shyamali Dharmage, and John Hopper.