Journal article

Increased expression and co-localization of ACE, angiotensin II AT1 receptors and inducible nitric oxide synthase in atherosclerotic human coronary arteries

M Ohishi, GJ Dusting, PA Fennessy, FAO Mendelsohn, XC Li, JL Zhuo

International Journal of Physiology, Pathophysiology and Pharmacology | Published : 2010

Abstract

Using immunohistochemistry and quantitative in vitro autoradiography, the present study was undertaken to examine whether co-expression of pro-atherosclerotic factors, ACE, the AT1 receptor, and iNOS, is increased in early and advanced atherosclerotic lesions of human coronary arteries. In normal coronary arteries, ACE and eNOS were strongly co-expressed in endothelial cells (ECs), whereas the AT1 receptor was expressed in medial smooth muscle cells (SMCs). By contrast, iNOS was not expressed in ECs and SMCs. In early atherosclerotic lesions and atheromatous plaques, ACE, the AT1 receptor and iNOS immunostaining were primarily co-localized in infiltrated macrophages and SMCs adjacent to macr..

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