Journal article

Measurement of disability in multiple sclerosis

Orla Gray, Helmut Butzkueven

NEUROLOGY ASIA | ASEAN NEUROLOGICAL ASSOC | Published : 2008

Abstract

Despite its limitations, the Kurtzke Expanded Disability Status Scale (EDSS) is the gold standard in assessing physical disability in multiple sclerosis (MS). Sustained progression in EDSS has been used widely as the endpoint in therapeutic studies. However, the patients' disability often fluctuates or improves over time; and up to half of the patients with "sustained progression" of EDSS eventually regress to their baseline. It is, therefore, not a sensitive measure to define irreversible progression of disease. The Multiple Sclerosis Severity Score (MSSS) is a useful measure of MS severity, incorporating the EDSS and disease duration. It has some prognostic significance for individuals wit..

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