Characterisation of PfRON6, a Plasmodium falciparum rhoptry neck protein with a novel cysteine-rich domain
Nicholas I Proellocks, Lev M Kats, David A Sheffield, Eric Harissen, Casilda G Black, Karena L Waller, Ross L Coppel
INTERNATIONAL JOURNAL FOR PARASITOLOGY | ELSEVIER SCI LTD | Published : 2009
The pathological consequences of malaria infection are the result of parasite replication within red blood cells (RBCs). Invasion into RBCs is mediated by a large repertoire of parasite proteins that are distributed on the parasite surface and within specialised apical secretory organelles. As invasion is an essential step in the parasite life-cycle, targeting invasion-related molecules provides an avenue for therapeutic intervention. We have used genome and transcriptome data available for Plasmodium falciparum to identify proteins likely to be involved in RBC invasion. Of these candidates, we selected a protein which we have dubbed PfRON6 for detailed characterisation. PfRON6 contains a no..View full abstract
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
This work was Supported by the National Health and Medical Research Council (NHMRC). N.I.P. and L.M.K. are Supported by the Australian Postgraduate Award. D.A.S. is supported by an NHMRC Medical and Dental Scholarship. The authors thank Robert Huestis of the Victorian Bioinformatics Consortium for assistance with gene annotation.