Book Chapter

The Evolution of Genomic Imprinting - A Marsupial Perspective

Timothy A Hore, Marilyn B Renfree, Andrew J Pask, Jennifer A Marshall Graves

MARSUPIAL GENETICS AND GENOMICS | SPRINGER-VERLAG BERLIN | Published : 2010

Abstract

Genomic imprinting is a medically significant epigenetic trait in which genes are expressed from only one of the two alleles, according to their parent of origin. Among vertebrates, imprinted gene expression has been found only in the live-bearing therian mammals - eutherians (placental mammals) and marsupials. Because marsupials are so distantly related to eutherians, comparisons of imprinting between the two mammalian infraclasses are particularly valuable. However, the popular mammalian model organisms (humans, mice and domestic mammals) are all eutherian, so imprinting in marsupials has not received the attention it deserves. Research gathered over some years shows that marsupial ortholo..

View full abstract