Journal article

Dynamic knee loading is related to cartilage defects and tibial plateau bone area in medial knee osteoarthritis

MW Creaby, Y Wang, KL Bennell, RS Hinman, BR Metcalf, K-A Bowles, Flavia M Cicuttini



OBJECTIVE: To evaluate the relationship between dynamic mechanical loading, as indicated by external knee adduction moment (KAM) measures during walking, and measures of articular cartilage morphology and subchondral bone size in people with medial knee osteoarthritis (OA). DESIGN: 180 individuals with radiographic medial tibiofemoral OA participated. Peak KAM and KAM angular impulse were measured by walking gait analysis. Tibial cartilage volume and plateau bone area, and tibiofemoral cartilage defects were determined from magnetic resonance imaging using validated methods. RESULTS: Both peak KAM (coefficient=0.42, 95% confidence interval (CI) 0.04-0.79, P=0.03) and KAM impulse (coefficient..

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Awarded by NHMRC

Awarded by NHMRC Public Health (Australia)

Funding Acknowledgements

This study was supported by funds received from an NHMRC project grant (#350297). Dr Wang is the recipient of an NHMRC Public Health (Australia) Fellowship (#465142). Prof. Bennell is the recipient of an Australian Research Council Future Fellowship. Funding sources did not play a role in study design, collection, analysis and interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for publication.