Journal article
Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients
NI Rallón, S Naggie, JM Benito, J Medrano, C Restrepo, D Goldstein, KV Shianna, E Vispo, A Thompson, J McHutchison, V Soriano
AIDS | Published : 2010
Abstract
Background: Given that peginterferon-ribavirin treatment is poorly tolerated, there is interest in the identification of predictors of response, particularly in HIV/hepatitis C virus (HCV)-coinfected patients that respond less than HCV-monoinfected individuals. A single nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) has been shown to predict treatment response in HCV-monoinfected patients carrying genotype 1. Information is lacking for HIV/HCV-coinfected individuals and/or other HCV genotypes. Methods: From 650 HIV/HCV-coinfected patients, we identified those who had completed a course of peginterferon-ribavirin therapy with a validated outcome and available repository DNA. T..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
We would like to thank all patients who participated in the study. This work was supported in part by grants from Fundacion Investigacion y Educacion en SIDA (IES), Red de Investigacion en SIDA (RIS, FIS-RD06/0006), Agencia Lain Entralgo and the NEAT European project.