Journal article
Replicated Association Between an IL28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin
JJ McCarthy, JH Li, A Thompson, S Suchindran, XQ Lao, K Patel, HL Tillmann, AJ Muir, JG McHutchison
Gastroenterology | Published : 2010
Abstract
Background & Aims: Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is effective in less than 50% of those infected with HCV genotype 1. Genome-wide association studies have linked response to PEG-IFN/RBV with common single nucleotide polymorphisms in the vicinity of interferon (IFN)-λ genes on chromosome 19. We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients. Methods: A cross-sectional study of 1021 consecutive patients enrolled in the Duke Hepatology Clinic Research Database and Biorepository. We analyzed DNA, clinical and demo..
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Awarded by National Center for Research Resources
Funding Acknowledgements
These authors disclose the following: Drs Thompson and McHutchison are co-inventors with Schering Plough on a patent application on the original finding of rs12979860 association with pegylated interferon and ribavirin treatment response in HCV infection; Drs McHutchison and Muir have received research funding from and acted in an advisory capacity for Schering Plough. The remaining authors disclose no conflicts.This study was funded in part by a generous grant from the David H. Murdock Institute for Business and Culture via the M.U.R.D.O.C.K. Study and award 1 UL<INF>1</INF> RR024128-01 from the National Center for Research Resources, a component of the National Institutes of Health and National Institutes of Health Roadmap for Medical Research, and its contents are solely the responsibility of the authors and do not necessarily represent the official view of National Center for Research Resources or the National Institutes of Health. Dr Thompson received funding support from the Duke Clinical Research Institute, a generous research gift from the Richard B. Boebel Family Fund, the National Health and Medical Research Council of Australia, and the Gastroenterology Society of Australia.