Journal article

The 4-mg intravenous dexamethasone suppression test in the diagnosis of Cushing's syndrome

Caroline Jung, Frank P Alford, Duncan J Topliss, John R Burgess, Fiona Long, James J Gome, Jim R Stockigt, Warrick J Inder



OBJECTIVE: Optimal diagnostic criteria for the 4-mg intravenous dexamethasone suppression test (IVDST) in patients with Cushing's syndrome (CS), compared with normal subjects, have not been established. We evaluated the performance of the 4-mg IVDST for differentiating CS from normal subjects and to define the responses in CS of various aetiologies. DESIGN, SUBJECTS, MEASUREMENTS: Thirty-two control subjects [normal and overweight/obese participants with or without type 2 diabetes) were prospectively studied, and data from 66 patients with Cushing's disease (CD), three with ectopic ACTH syndrome (EAS), 14 with adrenal Cushing's (AC)] and 15 with low probability of CS (LPC) from three tertiar..

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Funding Acknowledgements

We thank Dr Ashley Ng and Dr Danny Liew for their assistance with statistical analysis, Colin Horner for providing information regarding assays and Reeta Singh for her help with data collection. This study was supported by a grant from St Vincent's Hospital and a research scholarship awarded to Dr C. Jung by the University of Melbourne.