Pathophysiology of septic acute kidney injury: A different view of tubular injury

Abstract

Septic acute kidney injury (AKI) is the most common form of AKI seen in critically ill patients in developed countries. Its pathogenesis has been traditionally attributed to ischemia secondary to decreased cardiac output and hypotension, which trigger sustained renal vasoconstriction and in turn exacerbate and sustain the ischemia. This paradigm is supported by the fact that many patients who develop AKI do so in the setting of hemodynamic instability and also by evidence that renal blood flow is decreased and renal vascular resistance increased when they are measured in patients with AKI. However, recent evidence shows that renal blood flow may vary from increased in some animal models to n..