The GABAAγ2(R43Q) mouse model of humangenetic epilepsy

Abstract

Summaryγ‐Aminobutyric acid (GABA)A receptors mediate phasic and tonic inhibition in the brain, and epilepsy‐associated mutations are found in GABAA genes. This chapter discusses a mouse model of human genetic epilepsy and how it has informed our understanding of the role of GABAA receptor dysfunction in patients. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado‐Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).