Identification of endocrine cells of the stomach that express acid-sensitive background potassium (K2P9.1/TASK3) channels

K Needham; L Pontell; B Hunne; M Thacker; D McHugh; JB Furness

Journal article

Identification of endocrine cells of the stomach that express acid-sensitive background potassium (K2P9.1/TASK3) channels

K Needham, L Pontell, B Hunne, M Thacker, D McHugh, JB Furness

Journal of Molecular Histology | SPRINGER | Published : 2010

DOI: 10.1007/s10735-010-9276-4

Abstract

The family of two-pore domain potassium (K2P) channels is important in setting and controlling the background potassium current of excitable cells. This study examines the localisation of the acid-sensitive channel, K2P9.1 (TASK3), in cells of the gastric mucosa. We observed K2P9.1 immunoreactivity in endocrine cells of the mucosal glands of the guinea-pig, rat and mouse but the channels were not detected in parietal, chief, or mucous cells. K2P9.1 channel immunoreactivity was consistently co-localised with histidine decarboxylase immunopositive enterochromaffin-like (ECL) cells, and with the majority of ghrelin immunoreactive X/A cells. Localisation in somatostatin immunoreactive D cells wa..

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University of Melbourne Researchers

John Furness Author

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Grants

Awarded by Novartis

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (grant 566696) and Novartis Pharmaceuticals AG. The authors wish to thank Dr B.A. Nayagam (University of Melbourne) for valuable feedback on the manuscript.