Cerebral palsy and assisted reproductive technologies: a case-control study
Susan M Reid, Alice M Jaques, Cynthia Susanto, Susan Breheny, Dinah S Reddihough, Jane Halliday
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | WILEY | Published : 2010
AIM: To determine whether assisted reproductive technologies (ART) were more likely to be the method of conception in singletons with cerebral palsy (CP) than in those without CP. METHOD: Singletons with CP born between 1991 and 2004 were selected from the Victorian Cerebral Palsy Register and matched for birth year to two singletons randomly selected from the Victorian Perinatal Data Collection Unit. Data from both sources were linked to records from three ART centres. Conditional logistic regression was used to assess the association between CP and aspects of conception using ART. Multivariate models were adjusted for parity, previous miscarriages, sex, gestational age, birthweight, and we..View full abstract
We are grateful to the BUPA Foundation, Professional Services Australia, the Waverley Branch of the Royal Children's Hospital Auxiliaries, and Solve! at the RCH for providing financial support for the study, and the Victorian Cerebral Palsy Register. The assistance of Melbourne IVF, Monash IVF, the other in vitro fertilization centres, and the Victorian Perinatal Data Collection Unit for the provision of data is also gratefully acknowledged.