Journal article
Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy
EJ Hamilton, E Gianatti, BJ Strauss, J Wentworth, D Lim-Joon, D Bolton, JD Zajac, M Grossmann
Clinical Endocrinology | Published : 2011
Abstract
Objective Androgen deprivation therapy (ADT) for prostate cancer is associated with increases in fat mass and risk of type 2 diabetes; however, the relationship between sex steroid deficiency and abdominal fat distribution remains controversial. Design We conducted a 12-month prospective observational study at a tertiary referral centre. Patients and measurements We investigated changes in abdominal fat distribution and insulin resistance in 26 men (70·6 ± 6·8 years) with nonmetastatic prostate cancer during the first year of ADT. Results Twelve months of ADT increased visceral abdominal fat area by 22% (from 160·8 ± 61·7 to 195·9 ± 69·7 cm2; P < 0·01) and subcutaneous abdominal fat area by ..
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Funding Acknowledgements
We thank Dr Ken Sharpe, from the Department of Mathematics and Statistics, the University of Melbourne, for advice and assistance with statistical analysis and for performing general linear model analysis. EJ Hamilton was supported by scholarships from the RACP (Rowling Trash and Treasure and Osteoporosis Australia research entry grants) as well as the University of Melbourne Medical Faculty (Viola Edith Reid scholarship) to undertake this project as part of PhD studies. M Grossmann was supported by a National Health and Medical Research Council of Australia Health Professional Research Fellowship, and by fellowships from the Royal Australasian College of Physicians as well as from Osteoporosis Australia.