Journal article
Methylprednisolone applied directly to the round window reduces dizziness after cochlear implantation: A randomized clinical trial
JC Enticott, HT Eastwood, RJ Briggs, RC Dowell, SJ O'Leary
Audiology and Neurotology | Published : 2011
DOI: 10.1159/000322137
Abstract
This prospective, double-blind controlled, randomized clinical trial of 43 adults showed that topical methylprednisolone applied to the round window during cochlear implantation was effective in protecting inner ear function. Postoperative vestibular disturbance was significantly lower in the steroid group (5%) than the control group (29%). Electrode impedances from the middle portion of the electrode array (electrodes 10-13) were significantly reduced in steroid-treated recipients compared to controls. Hearing and vestibular function analyses were under-powered to detect any drug changes due to limited participant data. Copyright © 2010 S. Karger AG, Basel.
Grants
Awarded by Royal Victorian Eye and Ear Hospital Human Research Ethics Committee
Funding Acknowledgements
This trial was registered with the Australian TGA and approved by the Royal Victorian Eye and Ear Hospital Human Research Ethics Committee (project 05/630HC). Funding was received from the Deafness Foundation, Vic., RVEEH and NHMRC.