The impact of experimental hypoperfusion on subsequent kidney function

Abstract

Objective: To investigate the short- and medium-term renal hemodynamic and functional responses to both short and sustained hypoperfusion. Subjects: Eleven Merinos ewes. Setting: Animal laboratory of the University Physiology Institute. Design: Prospective observational study. Interventions: Studies were performed in conscious sheep after unilateral nephrectomy with a vascular occluder and flow probe implanted on the remaining renal artery. In five sheep, renal blood flow (RBF) was reduced by 25, 50 and 75%, respectively, by acute vascular occlusion for 30 min at weekly intervals. In another six sheep, RBF was reduced by 80% for 2 h. Measurements and results: After 25, 50 or 75% renal hypope..