Journal article
A retrospective study of the impact of lifestyle on age at onset of huntington disease
MK Trembath, ZA Horton, L Tippett, V Hogg, VR Collins, A Churchyard, D Velakoulis, R Roxburgh, MB Delatycki
Movement Disorders | Published : 2010
DOI: 10.1002/mds.23108
Abstract
In transgenic mouse models of Huntington disease (HD) environmental enrichment significantly delays disease onset. A questionnaire-based survey of 154 adults with diagnosed HD (mean 4.2 years postdiagnosis) and a known IT15 CAG repeat length, explored whether premorbid lifestyle may relate to age-at-onset (AO). Participants were drawn from HD outpatient clinics in Australia and New Zealand. Premorbid physical, intellectual, and passive activity levels were used to generate scores in the categories of leisure, nonleisure (education, occupation and domestic duties) and total lifestyle. AO was associated with increased CAG repeat length as expected (r = -0.72, P < 0.001), but also with a lifest..
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Funding Acknowledgements
Trembath: Employment-MCRI. Zoe A. Horton: Employment-Childrens Hospital Westmead (Australia). Lynette Tippett: Grants-HRC, NFNZ, Matthew Oswin Memorial Trust, Faculty Res Dev Fund (UofA); Employment-University of Auckland (NZ). Virginia Hogg: Employment-Universties of Otago and Auckland (NZ), TMC. Veronica R. Collins: Grants-NHMRC, MCRI; Employment-MCRI, Andrology Australia, Monash University (Australia). Andrew Churchyard: Grants-FARA; Employment-Calvary Healthcare Bethlehem (Australia). Dennis Velakoulis: Employment-Melbourne Health; Royalties: ACER. Richard Roxburgh: Auckland District Health Board (NZ). Delatycki: Grants-NHMRC, FARA, MCRI, Jack Brockoff Foundation; Employment-MCRI, Austin Health (Australia). Martin B. Delatycki is a Practitioner Fellow of the National Health and Medical Research Council of Australia. The Health Research Council of New Zealand, and the Matthew Oswin Memorial Trust supported the New Zealand study.