The association between maternal diet during pregnancy and bone mass of the children at age 16

Abstract

Background/Objectives: Fetal life may be a critical period for the development and/or programming of metabolic systems, including the skeleton. However, it is unclear on the association between maternal nutrition during pregnancy and bone mass in their offspring at adolescence.Subjects/Methods: This was a birth cohort study of 216 adolescents (16.2±0.4 years). Dietary intake was measured by food frequency questionnaire. Bone densitometry was measured at the femoral neck, lumbar spine and total body by DXA. Results: After adjustment for confounders, bone mineral density (BMD) of the femoral neck was positively associated with magnesium density and negatively associated with fat density (all P..