Journal article
Molecular basis of cytokine receptor activation
AF Lopez, TR Hercus, P Ekert, DR Littler, M Guthridge, D Thomas, HS Ramshaw, F Stomski, M Perugini, R D'Andrea, M Grimbaldeston, MW Parker
IUBMB Life | Published : 2010
DOI: 10.1002/iub.350
Abstract
Cytokines are secreted soluble peptides that precisely regulate multiple cellular functions. Amongst these the GM-CSF/IL-3/IL-5 family of cytokines controls whether hematopoietic cells will survive or apoptose, proliferate, differentiate, migrate, or perform effector functions such as phagocytosis or reactive oxygen species release. Their potent and pleiotropic activities are mediated through binding to high affinity membrane receptors at surprisingly low numbers per cell. Receptor binding triggers a cascade of intracellular signaling events, including reversible phosphorylation of receptor subunits and associated signaling molecules, leading to multiple biological responses, with the preven..
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Funding Acknowledgements
We thank Guido Hansen for his major contributions to the crystallography aspects reviewed in this article. This work was supported by a National Health and Medical Research Council (NHMRC) Program Grant to A.F.L. and M.W.P., NHMRC Project Grants to M.W.P., T.R.H., M.Gu., R.D'A., M.Gr., and P.E., a Viertel Senior Medical Fellowship to P.E., a Peter Nelson Leukaemia Research Fund Fellowship to H.S.R., Grants from The Leukaemia Foundation and The Children's Cancer Centre Foundation to P.E., and Australian Cancer Research Foundation Grants to M.W.P. and A.F.L. M.W.P. is an Australian Research Council Federation Fellow and NHMRC Honorary Fellow.