Control of bacterial virulence by AraC-like regulators that respond to chemical signals
Ji Yang, Marija Tauschek, Roy M Robins-Browne
TRENDS IN MICROBIOLOGY | ELSEVIER SCI LTD | Published : 2011
This review highlights the exciting new finding that small molecule inducers have been found for some members of the AraC family of transcriptional regulators (AFTRs) that control the expression of virulence genes of pathogenic bacteria. Although effector-mediated activation of AFTRs involved in the regulation of sugar and alkylbenzoate catabolism (e.g. AraC and XylS) is well understood, until recently little was known about effector-mediated regulation of virulence gene expression. This led to the belief that regulation of virulence by AFTRs does not involve the direct recognition of chemical environmental signals. More recently, however, a growing number of virulence-associated AFTRs have ..View full abstract
Work in the laboratory of the authors is supported by research grants from the Australian National Health and Medical Research Council.