Journal article
Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection
JJ Miles, D Thammanichanond, S Moneer, UK Nivarthi, L Kjer-Nielsen, SL Tracy, CK Aitken, RM Brennan, W Zeng, L Marquart, D Jackson, SR Burrows, DS Bowden, J Torresi, M Hellard, J Rossjohn, J McCluskey, M Bharadwaj
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2011
Abstract
Hepatitis C virus (HCV) infection causes significant morbidity and mortality worldwide. T cells play a central role in HCV clearance; however, there is currently little understanding of whether the disease outcome in HCV infection is influenced by the choice of TCR repertoire. TCR repertoires used against two immunodominant HCV determinants - the highly polymorphic, HLA-B*0801 restricted 1395HSKKKCDEL1403 (HSK) and the comparatively conserved, HLA-A*0101-restricted, 1435ATDALMTGY1443 (ATD) - were analyzed in clearly defined cohorts of HLA-matched, HCV-infected individuals with persistent infection and HCV clearance. In comparison with ATD, TCR repertoire selected against HSK was more narrowl..
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Grants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (Grants 331312 and 208981) and the Australian Centre for Hepatitis and HIV Research. The flow cytometry facility at the University of Melbourne is supported by the Picchi Brothers Foundation.