Journal article

Clinical and experimental links between diabetes and glaucoma

Vickie HY Wong, Bang V Bui, Algis J Vingrys

CLINICAL AND EXPERIMENTAL OPTOMETRY | TAYLOR & FRANCIS LTD | Published : 2011

DOI: 10.1111/j.1444-0938.2010.00546.x

Abstract

Glaucoma is a leading cause of blindness. It is a multifactorial condition, the risk factors for which are increasingly well defined from large-scale epidemiological studies. One risk factor that remains controversial is the presence of diabetes. It has been proposed that diabetic eyes are at greater risk of injury from external stressors, such as elevated intraocular pressure. Alternatively, diabetes may cause ganglion cell loss, which becomes additive to a glaucomatous ganglion cell injury. Several clinical trials have considered whether a link exists between diabetes and glaucoma. In this review, we outline these studies and consider the causes for their lack of concordant findings. We al..

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University of Melbourne Researchers

Vickie Wong Author Optometry and Vision Sciences

Bang Bui Author Optometry and Vision Sciences

Algis Vingrys Author Optometry and Vision Sciences

Barry Cole Author Optometry and Vision Sciences

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Grants

Awarded by NHMRC

Funding Acknowledgements

The authors are supported by NHMRC project grants 400127, 475603, 566570 and 350224.

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Keywords

Ocular Blood-Flow

Metabolic and Endocrine

Protein-Kinase-C

Open-Angle Glaucoma

Endothelial Growth-Factor

Science & Technology

Intraocular Pressure

Eye Disease and Disorders of Vision

Life Sciences & Biomedicine

Retinal Ganglion-Cells

Nitric-Oxide Synthase

Neurodegenerative

Optic-Nerve Head

Scotopic Threshold Response

Retrograde Axonal-Transport

Intraocular-Pressure Elevation