Journal article

Repeat botulinum toxin-A injections in the upper limb of children with hemiplegia: a randomized controlled trial

Christine A Olesch, Susan Greaves, Christine Imms, Susan M Reid, H Kerr Graham



AIM: To test the effectiveness of repeat botulinum toxin A (BoNT-A) injections in the affected arm of 22 children with hemiplegic cerebral palsy (19 males, three females), aged 1 year 10 months to 4 years 10 months (mean 3y 8mo, SD 9mo) in a randomized controlled trial. METHOD: Children received either three series of BoNT-A injections plus twice-weekly occupational therapy (OT) or OT alone in 16-week cycles. Muscles targeted at each injection cycle in the 11 children receiving BoNT-A+OT were the adductor pollicis (n=9), flexor pollicis longus (n=5), flexor digitorum superficialis (n=8), flexor digitorum profundus (n=8), flexor carpi radialis (n=2), flexor carpi ulnaris (n=6), pronator teres..

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Funding Acknowledgements

We would like to express our gratitude to the children and their families who participated in the study, to the Murdoch Childrens Research Institute, the Department of Orthopaedic Surgery at the Royal Children's Hospital, Melbourne, and the Marian and EH Flack Trust for their financial contributions to the study, and to Allergan for providing the study medication. Special thanks go to Melinda Randall who performed the blinded occupational therapy assessments to Associate Professor Susan Donath for statistical advice.