Journal article

Thin Multilayer Films and Microcapsules Containing DNA Quadruplex Motifs

Francesca Cavalieri, Sher Leen Ng, Claudia Mazzuca, Zhongfan Jia, Volga Bulmus, Thomas P Davis, Frank Caruso

SMALL | WILEY-V C H VERLAG GMBH | Published : 2011

Abstract

The assembly of multifunctional nanostructures bearing G-quadruplex motifs broadens the prospects of using G-quadruplexes as therapeutic carriers. Herein, we report the synthesis and characterization of an oligodeoxyguanosine, G15-mer polymer conjugate. We demonstrate that G15-mer oligonucleotides grafted to a polymer chain preserve the ability to self-assemble into ordered structures. The G-quadruplex-polymer conjugates were assembled onto a surface via hybridization with 30-mer cytosine strands, C30-mer, using a layer-by-layer approach to form microcapsules. A mechanism for the sequential assembly of the multilayer films and microcapsules is presented. We further investigate the photophysi..

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