Retinal thinning in tree shrews with induced high myopia: Optical coherence tomography and histological assessment

CJ Abbott; U Grünert; MJ Pianta; NA McBrien

Journal article

Retinal thinning in tree shrews with induced high myopia: Optical coherence tomography and histological assessment

CJ Abbott, U Grünert, MJ Pianta, NA McBrien

Vision Research | Published : 2011

DOI: 10.1016/j.visres.2010.12.005

Abstract

This study determined retinal thinning in a mammalian model of high myopia using optical coherence tomography (OCT) and histological sections from the same retinal tissue. High myopia was induced in three tree shrews (Tupaia belangeri) by deprivation of form vision via lid suture of one eye, with the other eye a control. Ocular biometry data was obtained by Ascan ultrasonography, keratometry and retinoscopy. The Zeiss StratusOCT was used to obtain Bscans in vivo across the retina. Subsequently, eyes were enucleated and retinas fixed, dehydrated, embedded and sectioned. Treated eyes developed a high degree of axial myopia (-15.9 ± 2.3. D; n=3). The OCT analysis showed that in myopic eyes the ..

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University of Melbourne Researchers

Michael Pianta Author

Carla Abbott Author

Grants

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia Grants #255157 and #454602 to N.M<SUP>c</SUP>B., a Retina Australia Grant to M.J.P., a Lions Vision Research Fellowship to U.G. and an Ernst and Grace Matthaei Scholarship to C.J.A.