Journal article

Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis

M Hickey, DA Doherty, H Atkinson, DM Sloboda, S Franks, RJ Norman, R Hart

Human Reproduction | OXFORD UNIV PRESS | Published : 2011


BACKGROUND: Diagnosing polycystic ovary syndrome (PCOS) in adolescence is clinically challenging. The prevalence of clinical, ultrasound and biochemical features of PCOS in a community-based adolescent population using current diagnostic criteria has not previously been described. METHODS: This was a prospective cohort study with 244 unselected post-menarchal girls, mean age 15.2 years, of whom 91% were Caucasian. Subjects were recruited from a large population-based birth cohort (the Raine cohort). Clinical hyperandrogenism (HA) was quantified using Ferriman-Gallwey scores. In the early follicular phase (Day 2-6), we measured circulating androgens and sex hormone-binding globulin by immunoa..

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Awarded by NHMRC

Funding Acknowledgements

We are extremely grateful to all the families who took part in this study and the whole Raine Study team. We acknowledge both the Raine Medical Research Foundation at the University of Western Australia and the Telethon Institute of Child Health Research for financial support and general support over the years. We acknowledge LeeAnn Mahoney, Sarah Simpson and Helen Box for study recruitment, James Humphreys for database construction and maintenance and Prof Jan Dickinson for ultrasonography.The collection of maternal data and samples was funded by the Women and Infants' Research Foundation (WIRF) while the collection of adolescent data and samples was funded by NHMRC project grant number 403968 (CIA Hickey). M. H. is also funded by an NHMRC Clinical Career Development Award (number 404094).