Journal article
Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers
AK Win, JG Dowty, YC Antill, DR English, JA Baron, JP Young, GG Giles, MC Southey, I Winship, L Lipton, S Parry, SN Thibodeau, RW Haile, S Gallinger, L Le Marchand, NM Lindor, PA Newcomb, JL Hopper, MA Jenkins
Obstetrics and Gynecology | Published : 2011
Abstract
Objective: To investigate the association of body mass index (BMI) in early adulthood and endometrial cancer risk for carriers of a germline mutation in a DNA mismatch repair gene. Methods: We estimated the association between BMI at age 18-20 years and endometrial cancer risk for mismatch repair gene mutation carriers and, as a comparison group, noncarriers using 601 female carriers of a germline mutation in a mismatch repair gene (245 MLH1, 299 MSH2, 38 MSH6, and 19 PMS2) and 533 female noncarriers from the Colon Cancer Family Registry using a weighted Cox proportional hazards regression. Results: During 51,693 person-years of observation, we observed diagnoses of endometrial cancer for 12..
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Awarded by National Cancer Institute
Funding Acknowledgements
Supported by the National Cancer Institute, National Institutes of Health under RFA #CA-95-011 and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators. Collaborating centers include the Australasian Colorectal Cancer Family Registry (U01 CA097735), the USC Familial Colorectal Neoplasia Collaborative Group (U01 CA074799), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800), Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783), Seattle Colorectal Cancer Family Registry (U01 CA074794), and University of Hawaii Colorectal Cancer Family Registry (U01 CA074806). This work was also supported by a grant from NHMRC Australia (ID 400160) and a grant from the Cancer Council Victoria (ID 454695). Yoland Antill was funded by an early career seed grant from Cancer Agency of Victoria.