Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity
Brad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, W Douglas Fairlie, John A Flygare, David CS Huang, Wilhelmus JA Kersten, Michael FT Koehler, Guillaume Lessene, Kym Lowes, John P Parisot, Brian J Smith, Morey L Smith, Andrew J Souers, Ian P Street, Hong Yang, Jonathan B Baell
Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2011
Awarded by Leukemia and Lymphoma Society
Awarded by NHMRC
Awarded by NHMRC IRIISS
This work was supported by Fellowships and Grants from the Leukemia and Lymphoma Society (SCOR 7015-02). Crystallization trials were performed at the Bio21 Collaborative Crystallisation Centre, Victoria, Australia. We thank Peter Colman for useful discussions and also the NHMRC, the Victorian State Government, the Cancer Council of Victoria, the Australian Cancer Research Foundation, and the Australian Research Council for the following support: NHMRC Program Grant 461221; NHMRC IRIISS Grant #361646; Victorian State Government OIS grant; Cancer Council of Victoria, Fraser Fellowship to P. M. Colman (2002-2006); ACRE Equipment Grant (2002); ARC Future Fellowship; and NHMRC Project Grant 575561 to P.E.C.