R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC4 production by human eosinophils
Graham A Mackay, Alastair G Stewart
BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2011
Eosinophils play important roles in limiting parasitic infection and in allergic inflammation in the asthmatic airways. Activation of eosinophils by diverse stimuli, including prostaglandin D(2) (PD(2) ), leads to leukotriene C(4) (LTC(4) ) synthesis that contributes to the expulsion of parasites and to epithelial injury in allergic inflammation. Mesquita-Santos et al. in this issue of the journal describe a collaboration between the two PGD(2) receptors, DP(1) and DP(2) [also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes)] that is required to trigger LTC(4) synthesis. DP(1) receptors coupled to G(αs) increase adenylate cyclase activity and cAMP/ p..View full abstract
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We thank Ms Andrea Draper for the artwork in Figure 1. The authors' work is supported by NHMRC project grants 509001, 566776 and 628691.