HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism
Michael Roche, Martin R Jakobsen, Jasminka Sterjovski, Anne Ellett, Filippo Posta, Benhur Lee, Becky Jubb, Mike Westby, Sharon R Lewin, Paul A Ramsland, Melissa J Churchill, Paul R Gorry
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2011
Awarded by NIH/NIAID
This study was supported by a grant from the Australian Center for HIV and Hepatitis Virology Research (ACH2) to P. R. G. and M.J.C. and by a grant from NIH/NIAID to B. L. (R21 AI092218). M. R. is supported by a Monash University Postgraduate Research Scholarship. P. R. G. is the recipient of an Australian National Health and Medical Research Council (NHMRC) Level 2 Biomedical Career Development award. P. A. R. is the recipient of an NHMRC R. Douglas Wright Biomedical Career Development award. S. R. L. is the recipient of an NHMRC Practitioner Fellowship. We gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program, received by the Burnet Institute.