Building stable chains with motile agents: Insights into the morphology of enteric neural crest cell migration
Kerry A Landman, Anthony E Fernando, Dongcheng Zhang, Donald F Newgreen
JOURNAL OF THEORETICAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2011
A defining characteristic of the normal development of the enteric nervous system (ENS) is the existence of an enteric neural crest (ENC) cell colonization wave, where the ENC cells form stable chains often associated with axons and near the vascular network. However, within this evolving neural network, the individual ENC cell elements constantly move, change direction and appear to act independently of neighbors. Three possible hypotheses are investigated. The simplest of these postulates that the ENS follows the vascular network as a template. We present evidence which does not support this hypothesis. Two viable alternatives are either that (i) the axons muster the ENC cells, providing t..View full abstract
This work is supported by the Australian Research Council (ARC) and National Health and Medical Research Council (NHMRC). Kerry Landman is an ARC Professorial Fellow. Dr. Miles Epstein and Dr. Noah Druckenbrod kindly provided movies of avian ENC cells, from which Druckenbrod and Epstein (2007) was derived. Dr. Heather Young kindly discussed her movies of mouse ENC cells with us. Dr. Hideki Enomoto and his group clarified issues of the relationship of growth cones and ENC cells. Dr. Craig Smith supplied SoxE antibody. The Developmental Studies Hybridoma Bank (Iowa) supplied several antibodies used in this study.