Journal article
Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice
KT Murphy, V Cobani, JG Ryall, C Ibebunjo, GS Lynch
Journal of Applied Physiology | Published : 2011
Abstract
Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice. J Appl Physiol 110: 1065-1072, 2011. First published January 26, 2011; doi:10.1152/japplphysiol.01183.2010.- Counteracting the atrophy of skeletal muscle associated with disuse has significant implications for minimizing the wasting and weakness in plaster casting, joint immobilization, and other forms of limb unloading, with relevance to orthopedics, sports medicine, and plastic and reconstructive surgery. We tested the hypothesis that antibodydirected myostatin inhibition would attenuate the loss of muscle mass and functional capacity in mice during 14 or 21 days of unilateral hindlimb casti..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Funding Acknowledgements
[ "This study was supported by research grants from Pfizer Global Research and Development (USA) and in part from the National Health and Medical Research Council of Australia (NHMRC Project Grant 566820). K. T. Murphy is supported by a Biomedical Australian Fellowship from the NHMRC, and J. G. Ryall is supported by a Biomedical Overseas Research Fellowship from the NHMRC.", "C. Ibebunjo was a former employee of Pfizer, the organization that funded the research. No conflicts of interest, financial or otherwise, are declared by the author(s)." ]