Wnt Signaling Regulates Snai1 Expression and Cellular Localization in the Mouse Intestinal Epithelial Stem Cell Niche
Katja Horvay, Franca Casagranda, Agnes Gany, Gary R Hime, Helen E Abud
STEM CELLS AND DEVELOPMENT | MARY ANN LIEBERT, INC | Published : 2011
Snail genes are transcriptional repressors well known to play important roles in epithelial to mesenchymal transitions during both embryogenesis and cancer metastasis. Although they are generally regarded as markers of mesenchymal cells, Snail genes have also recently been implicated in regulating stem cell populations in both Drosophila and vertebrates. In this study we investigate Snai1, a member of the mouse Snail family, in the intestinal stem cell niche and examine the relationship between canonical Wnt signaling, a key regulatory pathway of intestinal stem cells, and expression and cellular localization of Snai1. Strong nuclear expression of Snai1 was detected in the crypt base columna..View full abstract
This work was supported by National Health and Medical Research Council (NH&MRC) Australia project grants to H.E.A. and G.R.H.