Journal article
Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination
MD Binder, J Xiao, D Kemper, GZM Ma, SS Murray, TJ Kilpatrick
Plos One | Published : 2011
Abstract
Multiple sclerosis (MS) is a complex demyelinating disease of the central nervous system. Current research has shown that at least in some cases, the primary insult in MS could be directed at the oligodendrocyte, and that the earliest immune responses are primarily via innate immune cells. We have identified a family of receptor protein tyrosine kinases, known as the TAM receptors (Tyro3, Axl and Mertk), as potentially important in regulating both the oligodendrocyte and immune responses. We have previously shown that Gas6, a ligand for the TAM receptors, can affect the severity of demyelination in mice, with a loss of signalling via Gas6 leading to decreased oligodendrocyte survival and inc..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a grant from the National Health and Medical Research Council Australia (grant number 566830). GZMM is supported by an Australian Postgraduate Award. JX is the recipient of a Betty Cuthbert Fellowship (#454330) from National Health and Medical Research Council Australia and Multiple Sclerosis Research Australia. The Florey Neuroscience Institutes is supported by funding provided from the Operational Infrastructure Scheme of the Department of Innovation, Industry and Regional Development, Victoria, Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.