Effector diversification within compartments of the Leptosphaeria maculans genome affected by repeat-induced point mutations

T Rouxel; J Grandaubert; JK Hane; C Hoede; AP Van De Wouw; A Couloux; V Dominguez; V Anthouard; P Bally; S Bourras; AJ Cozijnsen; LM Ciuffetti; A Degrave; A Dilmaghani; L Duret; I Fudal; SB Goodwin; L Gout; N Glaser; J Linglin; GHJ Kema; N Lapalu; CB Lawrence; K May; M Meyer; B Ollivier; J Poulain; CL Schoch; A Simon; JW Spatafora; A Stachowiak; BG Turgeon; BM Tyler; D Vincent; J Weissenbach; J Amselem; H Quesneville; RP Oliver; P Wincker; MH Balesdent; BJ Howlett

Journal article

Effector diversification within compartments of the Leptosphaeria maculans genome affected by repeat-induced point mutations

T Rouxel, J Grandaubert, JK Hane, C Hoede, AP Van De Wouw, A Couloux, V Dominguez, V Anthouard, P Bally, S Bourras, AJ Cozijnsen, LM Ciuffetti, A Degrave, A Dilmaghani, L Duret, I Fudal, SB Goodwin, L Gout, N Glaser, J Linglin Show all

Nature Communications | Published : 2011

DOI: 10.1038/ncomms1189

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Abstract

Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-r..

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University of Melbourne Researchers

Angela van de Wouw Author

Anton Cozijnsen Author

Barbara Howlett Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

We acknowledge Marc-Henri Lebrun (INRA-Bioger) and Francis Martin (INRA, Interactions arbres/micro-organismes, Champenoux, France) for support and advice. The genome sequencing of L. maculans was funded by the Genoscope, Institut de Genomique, CEA, France. The establishment of databases and interfaces was funded by Agence Nationale de la Recherche (GnpAnnot project; ANR-07-GPLA-051G). Wholegenome effector analysis was funded by ANR (FungEffector project; ANR-06-BLAN-0399). Recombination analysis and P.B. were funded by ANR (AvirLep project; ANR-07-GPLA-015). B.J.H and R.P.O. thank the Australian Grains Research and Development Corporation for funding. C.L.S was supported in part by the Intramural Research Program of the NIH, National Library of Medicine. J.W.S acknowledges support from the U.S. National Science Foundation, grant number DEB-0717476. B.M.T. was supported in part by the U.S. National Science Foundation, grant number IOS-0924861. Thanks are due to INRA-SPE department, the 'Leptosphaeria maculans' scientific and applied community, and the 'Dothideomycete' community for support of the L. maculans genome initiative.