Journal article

Cortisol and dehydroepiandrosterone-sulphate levels correlate with symptom severity in first-episode psychosis

Belinda Garner, Christina Phassouliotis, Lisa J Phillips, Connie Markulev, Felicity Butselaar, Sarah Bendall, Yang Yun, Patrick D McGorry

JOURNAL OF PSYCHIATRIC RESEARCH | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2011

Abstract

BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulphate form (DHEA) are neuroactive steroids with antiglucocorticoid properties. An imbalance in the ratio of cortisol to DHEA(S) has been implicated in the pathophysiology of stress-related psychiatric disorders. This study prospectively investigated circulating cortisol, DHEAS and their ratio in first-episode psychosis (FEP) patients compared to healthy controls, and their relationship to perceived stress, psychotic, negative and mood symptoms. METHODS: Blood cortisol and DHEAS levels were obtained in 39 neuroleptic-naïve or minimally-treated FEP patients and 25 controls. Twenty-three patients and 15 controls received repeat assessments af..

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