Copper Promotes the Trafficking of the Amyloid Precursor Protein
Karla M Acevedo, Ya Hui Hung, Andrew H Dalziel, Qiao-Xin Li, Katrina Laughton, Krutika Wikhe, Alan Rembach, Blaine Roberts, Colin L Masters, Ashley I Bush, James Camakaris
JOURNAL OF BIOLOGICAL CHEMISTRY | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2011
Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases the level of APP at the cell surface. Here we report that copper, but not iron or zinc, promotes APP trafficking in cultured polarized epithelial cells and neuronal cells. In SH-SY5Y neuronal cells and primary cortical neurons, copper promoted a redistribution of APP from a perinuclear localization to a wider distribution, including neurites. Importantly, a change in APP localization was not attrib..View full abstract
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This work was supported by grants from the National Health and Medical Research Council (to J. C. and A. I. B.). The FV1000 Olympus confocal microscope used for this work was co-funded by the Rowden White Foundation.Supported by the Australian Research Council.