Dietary Salt Intake and Mortality in Patients With Type 2 Diabetes
Elif I Ekinci, Sophie Clarke, Merlin C Thomas, John L Moran, Karey Cheong, Richard J MacIsaac, George Jerums
Diabetes Care | AMER DIABETES ASSOC | Published : 2011
OBJECTIVE: Many guidelines recommend that patients with type 2 diabetes should aim to reduce their intake of salt. However, the precise relationship between dietary salt intake and mortality in patients with type 2 diabetes has not been previously explored. RESEARCH DESIGN AND METHODS: Six hundred and thirty-eight patients attending a single diabetes clinic were followed in a prospective cohort study. Baseline sodium excretion was estimated from 24-h urinary collections (24hU(Na)). The predictors of all-cause and cardiovascular mortality were determined by Cox regression and competing risk modeling, respectively. RESULTS: The mean baseline 24hU(Na) was 184 ± 73 mmol/24 h, which remained cons..View full abstract
E.I.E. was supported by a National Health and Medical Research Council (NHMRC) medical postgraduate scholarship and by the Austin Hospital Medical Research Fund (AHMRF). E.I.E. and S.C. were both recipients of the Cardiovascular Lipid Research Grant from Pfizer for unconditional use of funding for research projects. S.C. was supported by AHMRF during data collection. M.C.T. is supported by the KHA Bootle bequest and a NHMRC senior research fellowship.