Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory
Yvette M Wilson, Thomas C Brodnicki, Andrew J Lawrence, Mark Murphy
BEHAVIOR GENETICS | SPRINGER | Published : 2011
The ability to learn and remember is variable within a population of a given species, including humans. This is due in part to genetic variation between individuals. However, only few genes have been identified that contribute to variation in learning and memory. Two inbred mouse strains, C57Bl/6J (B6) and DBA/2J (D2), show significant variation both in fear conditioning memory as well as primary responsiveness to fear. Several studies have identified quantitative trait loci (QTL) on chromosomes (Chr) 1 and 12 associated with performance in fear conditioning, but it is unclear if these QTL were associated with fear memory or innate fear responsiveness. To determine if these QTL are associate..View full abstract
These studies were supported by a project grant from the National Health and Medical Research Council of Australia. We also thank Katie Bankieris, Maggie Crowe, Catharine Jawahar, Margaret Pietrowski, Laura Smith and Lidia Trogrlic for their assistance in this work.