Journal article

Ciliate Pellicular Proteome Identifies Novel Protein Families with Characteristic Repeat Motifs That Are Common to Alveolates

Sven B Gould, Lesleigh GK Kraft, Giel G van Dooren, Christopher D Goodman, Kristina L Ford, Andrew M Cassin, Antony Bacic, Geoffrey I McFadden, Ross F Waller



The pellicles of alveolates (ciliates, apicomplexans, and dinoflagellates) share a common organization, yet perform very divergent functions, including motility, host cell invasion, and armor. The alveolate pellicle consists of a system of flattened membrane sacs (alveoli, which are the defining feature of the group) below the plasma membrane that is supported by a membrane skeleton as well as a network of microtubules and other filamentous elements. We recently showed that a family of proteins, alveolins, are common and unique to this pellicular structure in alveolates. To identify additional proteins that contribute to this structure, a pellicle proteome study was conducted for the ciliate..

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Awarded by Australian Research Council (ARC)

Funding Acknowledgements

This project was supported by a Discovery Project Grant (DP0664097) from the Australian Research Council (ARC). S. B. G. was supported by a German Research Foundation fellowship. We are grateful to Jacek Gaertig for assistance with Tetrahymena transformation. K. L. F., A. M. C., and A. B. acknowledge support of funding from the Australian Centre for Plant Functional Genomics. G. I. M. is an ARC Federation Fellow and a HHMI International Scholar. Program grant support from the National Health and Research Council is acknowledged.