Journal article
Advances in structural and molecular neuroimaging in Alzheimer's disease
KA Ellis, CC Rowe, CEI Szoeke, VL Villemagne, D Ames, G Chételat, RN Martins, CL Masters, J Fripp, O Acosta, P Raniga, PT Bourgeat, O Salvado
Medical Journal of Australia | AUSTRALASIAN MED PUBL CO LTD | Published : 2011
Abstract
• Longer life expectancies lead to increases in the prevalence of age-associated illnesses. The number of Australians with dementia is predicted to rise, from 234 000 in 2009 to over 1 million by 2050, as a result of the increased prevalence of Alzheimer's disease (AD), the leading cause of dementia in the elderly. • Early diagnosis of AD will become more important as diseasemodifying therapies emerge within the next decade. • Advances in molecular neuroimaging with amyloid-β-specific radioligands for positron emission tomography, aided by magnetic resonance imaging techniques, allow detection of AD years before symptoms of dementia develop. • Longitudinal prospective studies, such as the Au..
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Awarded by Dementia Collaborative Research Centres program
Funding Acknowledgements
[ "Core funding for the AIBL study was provided by the CSIRO and was matched by contributions from the study partners (see http://www.aibl.csiro.au). The study also receives support from the National Health and Medical Research Council and the Dementia Collaborative Research Centres program (DCRC2). Pfizer International has contributed financial support to assist with analysis of blood samples and to further the AIBL research program. The Alzheimer's Association (USA) has contributed support to allow AIBL neuroimaging stream data (and accompanying clinical and cognitive data) to be made available via the Alzheimer's Disease Neuroimaging Initiative website. We thank Alzheimer's Australia (Victoria and Western Australia) who have assisted with promotion of the study and screening of telephone calls from volunteers, and collaborated with AIBL volunteer functions. Cassandra Szoeke is partially supported by a research fellowship funded by Alzheimer's Australia. The AIBL team wishes to thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD.", "Cassandra Szoeke has received honoraria, to 2009, from Pfizer and Lundbeck and, to 2006, from Sanofi-Aventis and Mayne Pharma. David Ames has received remuneration for board membership of Pfizer, Novartis and Janssen-Cilag, and travel expenses from Novartis (2009)." ]