Journal article

Is Physical Activity a Risk Factor for Primary Knee or Hip Replacement Due to Osteoarthritis? A Prospective Cohort Study

Yuanyuan Wang, Julie Anne Simpson, Anita Wluka, Andrew J Teichtahl, Dallas R English, Graham G Giles, Stephen Graves, Flavia M Cicuttini



OBJECTIVE: To estimate prospectively any association between measures of physical activity and the risk of either primary knee or hip replacement due to osteoarthritis (OA). METHODS: Eligible subjects (n = 39,023) were selected from participants in a prospective cohort study recruited 1990-1994. Primary knee and hip replacement for OA during 2001-2005 was determined by linking the cohort records to the National Joint Replacement Registry. A total physical activity level was computed, incorporating both intensity and frequency for different forms of physical activity obtained by questionnaire at baseline attendance. RESULTS: There was a dose-response relationship between total physical activi..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Public Health (Australia)

Funding Acknowledgements

The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and The Cancer Council of Victoria. This study was supported by a program grant from the National Health and Medical Research Council (NHMRC; 209057), capacity building grant (251533), and enabling grant (396414), and was further supported by infrastructure provided by The Cancer Council of Victoria. Dr. Wang and Dr. Wluka received NHMRC Public Health (Australia) Fellowships (NHMRC 465142 and 317840, respectively).