Journal article
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk
S Lindström, CM Vachon, J Li, J Varghese, D Thompson, R Warren, J Brown, J Leyland, T Audley, NJ Wareham, RJF Loos, AD Paterson, J Rommens, D Waggott, LJ Martin, CG Scott, VS Pankratz, SE Hankinson, A Hazra, DJ Hunter Show all
Nature Genetics | Published : 2011
DOI: 10.1038/ng.760
Abstract
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10-10). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer. © 2011 Nature America, Inc. All rights reserved.
Grants
Awarded by Agency for Science, Technology and Research
Funding Acknowledgements
This study was supported by Public Health Service Grants CA131332, CA087969, CA049449, CA128931, CA116201, CA075016, CA122340 and CA089393 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services and Breast Cancer Research Fund. The Nurses' Health Study (NHS) breast cancer cases and controls were genotyped with support from the National Cancer Institute's Cancer Markers of Susceptibility (CGEMS) initiative. Data evaluation of mammograms and analysis of the EPIC-Norfolk and SIBS studies was supported by Cancer Research UK. The SASBAC study was supported by Marit and Hans Rausing's Initiative against Breast Cancer, National Institutes of Health, Susan Komen Foundation and Agency for Science, Technology and Research of Singapore (A*STAR). Genotyping in the TORONTO/MELBOURNE subjects was supported by the Campbell Family Institute for Breast Cancer Research. Support was also provided by the Ontario Ministry of Health and Long Term Care.